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ICI needn’t be withheld in these with autoimmune illness


(HealthDay)—For sufferers with superior melanoma, response to immune checkpoint inhibitors (ICIs) is comparable for these with and with out preexisting autoimmune illness (AID), in accordance with a examine revealed on-line Feb. 16 within the Annals of Inside Medication.

Monique Okay. van der Kooij, M.D., from Leiden College Medical Heart within the Netherlands, and colleagues carried out a nationwide cohort examine within the Netherlands to look at the security and efficacy of ICIs in 4,367 sufferers with superior melanoma with and with out AID; 9.5 p.c had AID.

The researchers discovered that for sufferers with AID, the incidences of immune-related antagonistic occasions of grade 3 or increased have been 30, 17, and 44 p.c for these handled with anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4), anti-programmed cell demise 1 (PD-1), and mixture remedy, respectively; for sufferers with out AID, the corresponding incidences have been 30, 13, and 48 p.c. In contrast with sufferers with out AID, these with AID extra usually discontinued anti-PD-1 therapy due to toxicity (17 versus 9 p.c). Anti-PD-1-induced colitis occurred extra usually in sufferers with inflammatory bowel illness. Sufferers with versus with out AID who have been handled with anti-CTL-4, anti-PD-1, and mixture remedy had comparable goal response charges (10 versus 16 p.c; 40 versus 44 p.c; and 39 versus 43 p.c, respectively). No distinction was seen in survival for these with and with out AID (median, 13 versus 14 months).

“We encourage physicians not to withhold ICI in most common AIDs,” the authors write.


Immune checkpoint inhibitor remedy tied to cardiac occasion danger


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ICI needn’t be withheld in these with autoimmune illness (2021, February 16)
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