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New Therapy Could Assist Infertility in Menopause – MedicineNet Well being Information


By Steven Reinberg HealthDay Reporter

An experimental remedy could restore fertility throughout early menopause, a small new examine claims.

Sometimes, menopause ends a lady’s means to get pregnant. However researchers report that administering platelet-rich plasma and hormones, known as gonadotropins, may stimulate ovulation to make being pregnant attainable.

“The most surprising finding in this work is awakening the sleeping beauty, restoration of ovulatory function after menopause,” mentioned lead researcher Dr. Chao Chin Hsu, from the division of obstetrics and gynecology at Nationwide Taiwan College Hospital in Taipei.

As ladies enter menopause, their ovaries lose regular operate and there are lower than 1,000 retained immature ovarian follicles. These immature follicles are usually proof against gonadotropin or different stimulants, he mentioned.

Extra ladies are delaying being pregnant till it turns into problematic, and about 12% of ladies expertise early menopause, when ovarian operate ceases at or earlier than age 45.

These ladies often want donor eggs to have an opportunity of turning into pregnant, however strategies that stimulate ovarian operate may make it attainable for a lady to turn into pregnant with out donor assist.

The researchers suppose that these preliminary outcomes could someday give hope to ladies in early menopause that they could get pregnant by way of in vitro fertilization utilizing their very own eggs.

Though platelet-rich plasma has been tried in ladies whose ovaries aren’t working, just a few pregnancies and births have resulted.

On this pilot examine, nevertheless, when 12 ladies’s ovaries had been injected with platelet-rich plasma and gonadotropins, 11 began to menstruate once more, and one turned pregnant.

“This treatment is another scenario for women in early menopause and those of impending ovarian failure to have better opportunity to conceive using their own eggs,” Hsu mentioned.

“Our study showed regain of follicle growth with elevated levels of the ovarian hormone estradiol in most menopause women who received our treatment, resulting in rejuvenation for early menopause women,” Hsu mentioned.

Additionally, the signs of early menopause is likely to be eased, he mentioned. “This treatment might also help prevent osteoporosis and cardiovascular diseases, or even dementia in menopausal women, but that needs future studies to prove,” Hsu famous.

The findings had been revealed on-line not too long ago within the journal Menopause.

Dr. Jennifer Wu, an obstetrician-gynecologist at Lenox Hill Hospital in New York Metropolis, was not a part of the analysis however reviewed the findings. She thinks the examine included too few ladies to attract definitive conclusions.

“The percentage success rate for a live birth is not known, and that’s what we’re really interested in,” Wu mentioned. “We can’t extrapolate any of that from these tiny numbers, but it’s very interesting and perhaps it would really work for younger patients who have what we call diminished ovarian reserve.”

In diminished ovarian reserve, the ovaries lose regular reproductive potential. The situation could consequence from illness or damage, however mostly happens on account of regular ageing. About 10% to 30% of ladies with infertility have the situation, and it’s a problem to deal with.

Wu is skeptical that this remedy used within the examine will profit ladies in menopause.

Most older sufferers could have a really onerous time getting pregnant, and even when they do get pregnant, they usually could have an irregular being pregnant that does not finish properly, she mentioned.

“The problem with stimulating periods and eggs is that the eggs may be there, but they may not be normal at that age,” Wu mentioned. “Even if you do achieve pregnancy, it’s not a good pregnancy. So, the question is, will this technology actually work better for a patient who’s a little younger and having trouble because there are fewer eggs.”


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Fertility Choices: Varieties, Therapies, and Prices
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Extra info

For extra on early menopause, see the American Pregnancy Association.

SOURCES: Chao Chin Hsu, MD, PhD, division of obstetrics and gynecology, Nationwide Taiwan College Hospital, Taipei, Taiwan; Jennifer Wu, MD, obstetrician-gynecologist, Lenox Hill Hospital, New York Metropolis; Menopause, March 31, 2021, on-line

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