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Analysis group identifies potential drug to deal with SARS-CoV-2


Novel Coronavirus SARS-CoV-2 Transmission electron micrograph of SARS-CoV-2 virus particles, remoted from a affected person. Picture captured and color-enhanced on the NIAID Built-in Analysis Facility (IRF) in Fort Detrick, Maryland. Credit score: Nationwide Institute of Allergy and Infectious Illnesses, NIH

A federally authorised coronary heart remedy exhibits important effectiveness in interfering with SARS-CoV-2 entry into the human cell host, in accordance with a brand new research by a analysis group from Texas A&M College and The College of Texas Medical Department (UTMB).

The remedy bepridil, which matches by the commerce title Vascor, is at present authorised by the U.S. Meals and Drug Administration (FDA) to deal with angina, a coronary heart situation.

The group’s leaders are Faculty of Science professor Wenshe Ray Liu, professor and holder of the Gradipore Chair within the Division of Chemistry at Texas A&M, and Chien-Te Kent Tseng, professor and director of the SARS/MERS/COVID-19 Laboratory at UTMB. Liu additionally holds joint college positions in Texas A&M’s schools of drugs and agriculture and life sciences.

“Only one medication is currently available, Remdesivir, to provide limited benefits to COVID-19 patients, and the virus may easily evade it,” Liu mentioned. “Finding alternative medicines is imperative. Our team screened more than 30 FDA/European Medicines Agency approved drugs for their ability to inhibit SARS-COV-2’s entry into human cells. The study found bepridil to offer the most potential for treatment of COVID-19. As a result, we are advocating for the serious consideration of using bepridil in clinical tests related to SARS-CoV-2.”

The Texas A&M-UTMB research is now accessible on the web site of the peer-reviewed Proceedings of the Nationwide Academy of Sciences (PNAS) and is scheduled for print publication on March 9.

The group, which incorporates six different researchers from Texas A&M and 4 from UTMB, now plans to advance their work to animal fashions with a possible for scientific trials.


Comply with the most recent information on the coronavirus (COVID-19) outbreak


Extra info:
Erol C. Vatansever et al, Bepridil is potent in opposition to SARS-CoV-2 in vitro, Proceedings of the Nationwide Academy of Sciences (2021). DOI: 10.1073/pnas.2012201118

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Texas A&M College

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Analysis group identifies potential drug to deal with SARS-CoV-2 (2021, February 22)
retrieved 22 February 2021
from https://medicalxpress.com/information/2021-02-team-potential-drug-sars-cov-.html

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