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When Is a Individual With COVID-19 Most Infectious?

FRIDAY, Aug. 27, 2021 (HealthDay Information)

New analysis delivers a solution to a burning query: When are COVID-19 sufferers most infectious?

The reply? Two days earlier than and three days after they develop signs.

The findings spotlight the significance of fast testing and quarantine if somebody is feeling sick, the research authors mentioned.

The researchers additionally discovered that contaminated individuals are extra more likely to be asymptomatic in the event that they caught the virus from a major case (the primary contaminated particular person in an outbreak) who was additionally asymptomatic.

“In previous studies, viral load has been used as an indirect measure of transmission,” mentioned research co-leader Dr. Leonardo Martinez, an assistant professor of epidemiology at Boston College’s Faculty of Public Well being.

“We wanted to see if results from these past studies, which show that COVID cases are most transmissible a few days before and after symptom onset, could be confirmed by looking at secondary cases among close contacts,” Martinez mentioned in a college information launch.

For the research, Martinez and his colleagues analyzed information from about 9,000 shut contacts of major instances within the Zhejiang province of China from January 2020 to August 2020. That is earlier than the appearance of the much more contagious Delta variant.

Shut contacts included individuals who lived in the identical family or who dined collectively, co-workers, folks in hospital settings and riders in shared automobiles. They had been monitored for at the very least 90 days after their preliminary optimistic COVID-19 take a look at outcomes.

Of the first instances, 89% developed gentle or average signs, 11% had been asymptomatic, and none had extreme signs.

Family contacts of major instances and individuals who had been uncovered to major instances a number of instances or for longer quantities of time had larger an infection charges than different shut contacts, the findings confirmed.

However all shut contacts had been extra more likely to be contaminated by the first case in the event that they had been uncovered shortly earlier than or after that particular person developed signs, in keeping with the research printed on-line Aug. 23 in JAMA Internal Medicine.

Compared to gentle and average symptomatic major instances, those that had been asymptomatic had been a lot much less more likely to infect shut contacts. In the event that they did, the contacts had been additionally much less more likely to have noticeable signs, the researchers reported.

“Our results suggest that the timing of exposure relative to primary-case symptoms is important for transmission, and this understanding provides further evidence that rapid testing and quarantine after someone is feeling sick is a critical step to control the epidemic,” Martinez mentioned. “This study further emphasizes the need for vaccination, which reduces clinical severity among people that develop COVID.”

Extra info

The U.S. Facilities for Illness Management and Prevention has extra on COVID-19.

SOURCE: Boston College Faculty of Medication, information launch, Aug. 26, 2021

Robert Preidt


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