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White matter adjustments in mind present in frontotemporal dementia


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Areas of mind harm known as white matter hyperintensities are generally linked to vascular well being issues. They’ve additionally been linked to Alzheimer’s illness. Now a brand new research has proven that white matter hyperintensities are additionally present in frontotemporal dementia. The research is revealed within the February 17, 2021, on-line difficulty of Neurology. Frontotemporal dementia, which frequently impacts individuals underneath the age of 65, primarily ends in adjustments in character, habits and issues with language reasonably than reminiscence.

“We were expecting to see similar amounts of white matter hyperintensities in frontotemporal dementia and Alzheimer’s disease, but we actually found higher levels in people with frontotemporal dementia,” mentioned research creator Ramón Landin-Romero, Ph.D., of the College of Sydney in Australia. “We also expected to see that people with more severe disease would have more white matter hyperintensities, regardless of disease, but that was only true in people with frontotemporal dementia.”

The research concerned 64 individuals with frontotemporal dementia, 65 individuals with Alzheimer’s illness and 66 individuals with out dementia who had mind scans and different checks. The contributors had been adopted for a median of two years. Post-mortem info was out there for 13 of the individuals with frontotemporal dementia and 5 of the individuals with Alzheimer’s illness.

The researchers discovered that the entire quantity of white matter hyperintensities within the mind was bigger in individuals with frontotemporal dementia than within the individuals with Alzheimer’s illness or the wholesome management group. The typical quantity of white matter hyperintensities in individuals with frontotemporal dementia was 0.76 milliliters (mL) in comparison with 0.40 mL in individuals with Alzheimer’s illness and 0.12 mL in individuals with out dementia.

The quantity of white matter hyperintensities was related to the severity of an individual’s frontotemporal dementia, together with the severity of their signs and on a regular basis difficulties, however it was not related to having vascular danger elements akin to hypertension and excessive ldl cholesterol as was anticipated.

“In general, white matter hyperintensities have been associated with these vascular risk factors, so these results suggest that white matter hyperintensities are partly independent of vascular factors and associated with the progressive loss of brain integrity, more specifically the loss of brain cells, due to frontotemporal dementia,” Landin-Romero mentioned. “White matter hyperintensities should be viewed as a core feature of frontotemporal dementia and Alzheimer’s disease that can contribute to cognitive problems, not simply a marker of vascular disease.”

The researchers additionally discovered that increased quantities of white matter hyperintensities in sure areas of the mind had been related to worse cognitive efficiency. For instance, in each frontotemporal dementia and Alzheimer’s illness, elevated white matter hyperintensities within the corpus callosum, a bundle of white matter fibers connecting the left and proper hemispheres of the mind, was related to consideration issues.

A limitation of the research was that post-mortem info was out there for under a small variety of circumstances, so the underlying molecular reason behind the white matter hyperintensities couldn’t be decided for contributors.


Prediabetes could also be linked to worse mind well being


Offered by
American Academy of Neurology

Quotation:
White matter adjustments in mind present in frontotemporal dementia (2021, February 17)
retrieved 17 February 2021
from https://medicalxpress.com/information/2021-02-white-brain-frontotemporal-dementia.html

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